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KMID : 0363120190320040256
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Korean Journal of Pain
2019 Volume.32 No. 4 p.256 ~ p.263
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Antinociceptive and anti-inflammatory effects of N-acetylcysteine and verapamil in Wistar rats
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Elberry Ahmed Abdullah
Sharkawi Souty Mouner Zaky
Wahba Mariam Rofaiel
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Abstract
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Administration of NAC showed significant prolongation of hot plate latency time at 1 hour when compared to the control group while verapamil showed a significant prolongation of hot plate latency time at 1 and 2 hours when compared to the control group and NAC group values. Administration of NAC and verapamil significantly decreased paw edema thickness at 2, 4, and 8 hours when compared to edema control values. Regarding biochemical markers, NAC and verapamil significantly decreased serum nitric oxide synthase, C-reactive protein, and cyclooxygenase-2 levels compared to the edema control value. In accordance, a marked improvement of histopathological findings was observed with both drugs.
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KEYWORD
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Anti-Inflammatory Agents, Antinociceptive, Cyclooxygenase 2, Diclofenac, Edema, Nitric Oxide Synthase, Pain Measurement, Verapamil
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